BIOcoretheorySem 3

DRUG DELIVERY

BME 4404

Syllabus

01Drug delivery system: overview, dosage form-tablet, capsule, parenteral etc. classification of drug delivery system
02Chemically controlled system, diffusion-controlled system
03Controlled release mechanism - Membrane reservoir system, Matrix system, swelling controlled release system, biodegradable controlled release system
04Fundamental aspects of drug delivery: introduction of pharmacokinetics and pharmacodynamics, diffusive transport, diffusion in heterogeneous system, passage of drug through membrane
05Drug release kinetics from different bio polymer matrices
06Pharmacokinetics: common routes of systemic drug administration, drug absorption, bio availability, determinants of bio availability - disintegration, dissolution, drug distribution, drug elimination
07Matrix based drug delivery system: Delivery materials, polymer-based matrices; hydrogels - drug carriers, transdermal and trans-mucosal drug delivery system
08Measuring in vitro diffusions, measuring controlled release kinetics, drug targeting approaches, bio compatibility aspects of matrices
09Immunity and immunological preparations: immunity, types, immunological preparations; bacterial vaccines, vaccines containing living viruses, vaccines containing toxoids
10Fundamentals of vaccine delivery

B. Wang, T. J. Sahaan, R. A. Soltero, Drug Delivery: Principles and applications, John Wiley & Sons Inc., 2016.
L Shargel, S Wu-Pong, A Yu, Applied Biopharmaceutics & Pharmacokinetics, 6th Edition, The McGraw Hill, 2005.
S. Rosenbaum, Basic Pharmacokinetics and Pharmacokinetics, Wiley, 2011.
Juergen Siepmann, Ronald A. Siegel, Michael J. Rathbone (Editors), Fundamentals and Applications of Controlled Release Drug Delivery, Springer, 2012.
Eric P. Holowka, Sujata K. Bhatia, Drug Delivery-Materials Design and Clinical Perspective, Springer, 2014.
David Williams, Essentials of Biomaterials Science, Cambridge University press, 2014.

Credits Structure

3Lecture

0Tutorial

0Practical

3Total